November 9, 2020, will be a red letter day in the history of mankind. Pfizer and Biontech brought good news only as the whole world was lost in the corona virus outbreak, declaring that their invented mRNA vaccine was more than 90 percent effective in corona prevention. The findings came in the aftermath of a study of the latest update of six countries’ Phase 3 clinical trials of their vaccine.The 43,500 vaccines taker and placebo (dummy vaccine) study recipients, only 94 were covid-infected.
Infections among recipients of the original vaccine and placebo have shown that 90 out of every 100 recipients of the vaccine remain free of corona infection. 70-75 percent of diseases can typically be avoided by a vaccine. It is then treated as an effective vaccine. Initially, scientists were unsure about the corona vaccine.In such a short time, we have no history of producing an successful and healthy vaccine. In view of the massive loss of life, time limitations and the magnitude of the disease worldwide, scientists decided that it would be allowed to be given to the public with special consideration if a vaccine was even 50 percent successful. Everybody has been excited by the 90% efficacy of the Pfizer vaccine.
Pfizer will study the final results of the Phase 3 trial of their vaccine after 174 vaccine recipients have been infected with Covid. The theory is that the efficacy of the vaccine may be significantly reduced from 90% in the final review of the findings.It is estimated that the efficacy of the vaccine may be decreased by 90% when the findings of the four-part series are checked. The organization expects to manufacture 50 million doses of vaccine by the end of this year, with the UK providing 10 million doses of vaccine and the remainder in the United States. Since this country has already paid for vaccines in advance. Over the next year, Pfizer will produce another 130 million vaccine doses worldwide.
As the news from Pfizer brought us the excitement and hope, the company’s share price has jumped to the top! One thing is for sure, but here, Pfizer has just released the findings of the functionality of the vaccine. However, another very critical aspect of the findings remains uncertain, i.e. the efficacy or safety of the vaccine.While their vaccine had no significant adverse effects, they didn’t say anything about it.There are explanations for this. The rules apply to a vaccine which needs a minimum of two months to wait. Seeing any adverse side effects. Pfizer is going to have to wait for two weeks to get this information. The findings are expected to be announced by the end of November. This will be accompanied by a full statement of the provisional effects of the vaccine. There are also some other important issues which remain unanswered as regards the efficacy of the vaccine.For example, 94 of the participants in the vaccine trial were infected with covid. However, the trial did not see how many of the vaccine-borne people had been infected with the corona virus. Corona infection and covid are not the same. When a person is infected with the corona virus, he is called covid. But if one is infected with the corona virus. But without showing any signs of the disease, he was called asymptomatic infection.
Such asymptomatic patients, even if they do not show symptoms, spread the virus in the same way as a covid patient. Pfizer’s vaccine is 90 percent protected from covid, but how much of it prevents the asymptomatic infection remains unknown. If a vaccine does not effectively prevent the asymptomatic infection. So it’s hard to control the epidemic with that vaccine.Another important issue is the fact that Pfizer’s vaccine is effective on older people. The answer is still unknown. The old people are dying in The Covid. If a vaccine is not effective on older people. But the average death rate in Corona with that vaccine will not be reduced. Oxford and AstraZeneca, however, have shown in the Phase II trial that the chadox vaccine they have created is equally effective for older people.
The vaccine also remains a subject of future research on how long the vaccine will protect against the infection.Since the vaccine is made on a brand new and unrecognized platform, it is completely unknown what the long-term side effects may be. Pfizer’s vaccine is a vaccine made on an MRNA platform that has been stored since production at the lowest temperature of the – 70 degrees Celsius. If you cannot store and supply at this temperature, the main ingredient of the vaccine, the nucleic acid, breaks down very quickly and this destroys the function of the vaccine. Many see this sensitivity of temperature as the main barrier to the supply of vaccines. Such a cool (-70 degree) container for the supply of vaccines is also not available in many advanced countries of the world. In this case, it is normal to not have such a cold chain system in developing countries.
Pfizer has created a special kind of ‘cool box’ keeping in mind this obstacle in vaccine delivery. This cool box with a capacity of 5,000 vaccine vials will be the size of a small suitcase inside which the extremely cold temperature will be controlled with a dry ice bucket. This cool box can store and supply 5,000 vials of vaccine at a temperature of -70 degrees Celsius for 10 days in a row without any freezer or special container. In this way, the vaccine will be supplied to the remote areas of the country through cool boxes from the regional centers. So the inclusion of this cool box in the country’s conventional cold chain will make it possible to deliver the mRNA vaccine. And this cool box is reusable, which means this special cool box can be used repeatedly with dry ice.
All in all, the Pfizer vaccine is a blessing in disguise for this epidemic. However, it is important to carefully monitor whether the vaccine has any far-reaching side effects. The tide of vaccine world change is coming.